Research
I'm a Vancouver-based graduate student at the British Columbia Centre for Excellence in HIV/AIDS.
I study the use of next-generation ultra-deep pyrosequencing technology in HIV research and treatment, especially in its application to HIV coreceptor-usage and antiretroviral drug resistance.
I study the use of next-generation ultra-deep pyrosequencing technology in HIV research and treatment, especially in its application to HIV coreceptor-usage and antiretroviral drug resistance.
Deep V3 Sequencing for HIV Type 1 Tropism in Treatment-Naïve Patients: A Reanalysis of the MERIT Trial of Maraviroc
Swenson LC, Mo T, Dong WWY, Zhong X, Woods CK, Thielen A, Jensen MA, Knapp DJHF, Chapman D, Portsmouth S, Lewis M, James I, Heera J, Valdez H, Harrigan PR. Clinical Infectious Diseases 2011; 53(7): 732-742.
Detection of Inferred CCR5- and CXCR4-Using HIV-1 Variants and Evolutionary Intermediates Using Ultra-Deep Pyrosequencing
Bunnik EM, Swenson LC, Edo-Matas D, Huang W, Dong W, Frantzell A, et al. PLoS Pathogens. 2011 Jun 23;7(6):e1002106.
Reply to Abbate et al
Luke C Swenson & P Richard Harrigan. Journal of Infectious Diseases 2011;204(6): 973-974.
“Dynamic Range” of Inferred Phenotypic HIV Drug Resistance Values in Clinical Practice
Luke C. Swenson, Graham Pollock, Brian Wynhoven,Theresa Mo, Winnie Dong, Robert S. Hogg, Julio S. G. Montaner, P. Richard Harrigan. PLoS ONE 6(2): e17402. doi:10.1371/journal.pone.0017402
Mutations in gp41 are correlated with coreceptor tropism but do not improve prediction methods substantially
Thielen A, Lengauer T, Swenson LC, Dong WW, McGovern RA, Lewis M, James I, Heera J, Valdez H, Harrigan PR. Antivir Ther. 2011;16(3):319-28.
Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3 (Video Article)
McGovern RA, Harrigan PR, Swenson LC. Journal of Visualized Experiments 2010; 48: http://www.jove.com/details.stp?id=2531, doi: 10.3791/2531.
Deep Sequencing to Infer HIV-1 Co-Receptor Usage: Application to Three Clinical Trials of Maraviroc in Treatment-Experienced Patients
Luke C. Swenson, Theresa Mo, Winnie W.Y. Dong, Xiaoyin Zhong, Conan K. Woods,Mark A. Jensen, Alexander Thielen, Douglass Chapman, Marilyn Lewis, Ian James,Jayvant Heera, Hernan Valdez, and P. Richard Harrigan. Journal of Infectious Diseases 2011; 203(2): 237-245
Improved Detection of CXCR4-Using HIV by V3 Genotyping: Application of Population-Based and "Deep" Sequencing to Plasma RNA and Proviral DNA
Swenson LC, Moores A, Low AJ, Thielen A, Dong W, Woods C, Jensen MA, Wynhoven B, Chan D, Glascock C, Harrigan PR. Journal of Acquired Immune Deficiency Syndromes 2010; 54(5): 506-510.
Genotypic determination of HIV-1 tropism in the clinical setting
Swenson LC, Boehme R, Thielen A, McGovern RA, Harrigan PR. HIV Therapy 2010; 4(3): 293-303.
HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins
Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, Riddler SA, Haubrich R, Walker BD, Harrigan PR, Heckerman D, Mallal S. PLoS ONE 2009; 4(8): e6687.
Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, Riddler SA, Haubrich R, Walker BD, Harrigan PR, Heckerman D, Mallal S. PLoS ONE 2009; 4(8): e6687.
HIV co-receptor phenotyping in the clinical setting
Low AJ, Swenson LC and Harrigan PR. AIDS Rev 2008; 10 (3):143-51.
The Determinants and Consequences of HIV Coreceptor Switching
Harrigan R, Swenson L, McGovern R and Pollock G. HIV Medical Update 2009; 4(4).
